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Antimicrobials to Control Campylobacter

Agriculture
Livestock Animal Health
Livestock Animal Therapeutics
College
College of Food, Agricultural, and Environmental Sciences (CFAES)
Researchers
Rajashekara, Gireesh
Acuna, Ulyana Munoz
Antwi, Janet
Carcache de Blanco, Esperanza
Fuchs, James
Kumar, Anand
Nislow, Corey
Pascall, Melvin
Licensing Manager
Dahlman, Jason "Jay"
(614)292-7945
dahlman.3@osu.edu

T2016-058

The Need: Addressing the Growing Threat of Foodborne Illness

Foodborne illnesses caused by bacterial pathogens pose a significant public health concern worldwide, leading to millions of illnesses and thousands of deaths each year. Traditional antimicrobial therapies are facing challenges due to the increasing development of bacterial resistance. To effectively combat foodborne infections and prevent potential outbreaks, there is an urgent need for innovative broad-spectrum antimicrobial compounds that can tackle a range of bacterial pathogens.

The Technology: Broad-Spectrum Antimicrobial Compounds

The present technology introduces groundbreaking broad-spectrum antimicrobial compounds: JA-144, TH-04, and TH-08. These novel compounds, along with their derivatives and pharmaceutically acceptable salts, have demonstrated exceptional efficacy against a wide array of pathogenic bacteria. They provide a new generation of effective antimicrobials to combat foodborne infections and reduce the risk of contamination in food processing and handling.

Commercial Applications:

  1. Food Industry: The technology offers a powerful tool to prevent and control microbial contamination in food products. Incorporating these antimicrobial compounds into active food packaging systems can significantly extend the shelf life of perishable goods and enhance food safety.
  2. Medical Applications: The antimicrobial compounds can be utilized for pharmaceutical purposes in the treatment of bacterial infections. Their broad-spectrum nature makes them effective candidates for combating diverse bacterial strains, offering hope for improved therapeutic outcomes.
  3. Agriculture and Livestock: Implementing these antimicrobials in animal husbandry can help prevent the spread of bacterial infections, reducing the risk of foodborne diseases originating from contaminated meat and poultry.

Benefits/Advantages:

  1. Broad-Spectrum Efficacy: JA-144, TH-04, and TH-08 demonstrate potent antimicrobial activity against a wide range of bacteria, including Gram-negative, Gram-positive, and other bacterial strains, making them highly versatile and effective in multiple applications.
  2. Resistance Mitigation: As a new generation of antimicrobials, these compounds offer a fresh approach to address bacterial resistance, minimizing the likelihood of treatment failures and improving overall treatment outcomes.
  3. Enhanced Food Safety: By incorporating the antimicrobial compounds into active food packaging, the technology can significantly reduce bacterial growth, extending the shelf life of food products and ensuring safer consumption.
  4. Versatile Applications: The technology's potential spans various industries, including food, pharmaceuticals, agriculture, and livestock, allowing for widespread adoption and impact across different sectors.

In conclusion, the broad-spectrum antimicrobial compounds presented in this technology provide an essential solution to combat the growing threat of foodborne illnesses and bacterial infections. Their efficacy, resistance mitigation, and diverse applications make them a powerful tool in ensuring public health safety and advancing the fields of food processing, medicine, and agriculture. Embrace the future of antimicrobial innovation with our groundbreaking technology.