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Cellular Treatment of Metabolic Disorders

Life Sciences
Therapeutics
College
College of Education & Human Ecology
Researchers
Ziouzenkova, Ouliana
Licensing Manager
Flammang, Ann Marie
614-292-9839
flammang.2@osu.edu

TS-014787 — The implantation of engineered thermogenic cells for treating metabolic disease

Obesity is one of the leading preventable causes of death worldwide, and is progressively becoming more prevalent on a global scale. The condition dramatically increases the risk of many adverse physical and mental conditions including type 2 diabetes, cancers, and cardiovascular disease. Obesity …

The Need

Obesity is one of the leading preventable causes of death worldwide, and is progressively becoming more prevalent on a global scale. The condition dramatically increases the risk of many adverse physical and mental conditions including type 2 diabetes, cancers, and cardiovascular disease. Obesity is a complex psycho-somatic disorder attributed to both patient lifestyle factors and basal metabolism. Lifestyle change can be extremely effective, but severely obese patients often do not maintain compliance and weight gain is usually the consequence. Current surgical procedures aimed at treating obesity carry an array of post-operative complications, and even fatality. Consequently, non-invasive obesity treatments are increasingly in demand.

    The Technology

    Certain thermogenic fat cells possess a remarkable ability to burn fat and produce heat; however, these fat cells are very rare. Increased proportions of thermogenic cells in humans and animals are associated with reduced weight and high insulin sensitivity. Researchers at The Ohio State University, led by Dr. Ouilana Ziouzenkova, discovered a process of cellular engineering that allows the conversion of any fat cell into that of a thermogenic fat cell. Utilizing this approach as a novel obesity treatment, the basal metabolic rate can be dramatically increased. Additionally, this non-invasive cellular approach carries none of the adverse effects associated with surgical procedures, such as gastric restriction.

    Commercial Applications

    • Treatment of metabolic disorders including:
      • Obesity
      • Hyperglycemia
      • Inflammatory diseases
      • Obesity-related cancers

    Benefits/Advantages

    • Reduction of fat in specific fatty deposits
    • Increase in basal metabolic rate, leading to weight reduction
    • The number and function of implanted engineered cells is easily controlled
    • Engineered cells are encapsulated in biocompatible polymeric membranes which does not elicit an immune response