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Novel Engineered Probiotic to Prevent or Treat Salmonella

Healthcare Portfolios
Life Sciences
Veterinary Medicine
Animal Nutrition
Animal Therapeutics
Biologics
Companion Animal Health
Food Animal Health
Gastroenterology & Digestive Disease
Therapeutics
College
College of Medicine (COM)
Researchers
Ahmer, Brian
Sabag-Daigle, Anice
Licensing Manager
Dahlman, Jason "Jay"
614/292-7945
dahlman.3@osu.edu

TS-014970 — Novel engineered probiotic that competes specifically with the pathogen Salmonella for vital nutrients in the inflamed intestine of humans and livestock to prevent or treat infection.

Salmonella is a genus of bacteria that is a major cause of foodborne illness throughout the world. The illness usually lasts 4-7 days, and most people recover without treatment. However, in the very young and the elderly, and in cases where the bacteria has entered the bloodstream, antibiotherapy …

The Need

Salmonella is a genus of bacteria that is a major cause of foodborne illness throughout the world. The illness usually lasts 4-7 days, and most people recover without treatment. However, in the very young and the elderly, and in cases where the bacteria has entered the bloodstream, antibiotherapy may be needed. (WHO). Every year, approximately one million people in the U.S. are infected with Salmonella, causing 19,000 hospitalizations and 380 deaths (CDC). In 2016, there were eight multistate outbreaks of human Salmonella infections linked to live poultry in backyard flocks. These resulted in 895 cases of infection, 209 hospitalizations, and 3 deaths. (CDC). Currently, live attenuated Salmonella strains are used to vaccinate poultry. Although a vaccine can protect against a single serotype of Salmonella, it is ineffective in protecting against the other hundreds of serotypes that can cause gastroenteritis. Salmonella control within farms and processing plants has proven to be expensive and difficult, and elimination of the bacteria would be nearly impossible. Introducing a probiotic that can thwart the colonization and proliferation of harmful strains of Salmonella and that can easily be administered independently or jointly with other probiotic cocktails or food additives could provide a cost­ effective means for reducing human illness and death due to Salmonella.

The Technology

Researchers at The Ohio State University, led by Dr. Ahmer, have developed a novel modified Salmonella strain that cannot cause disease but competes specifically with Salmonella for the nutrients in the intestine that are critical to Salmonella growth. This prevents Salmonella proliferation and unnecessary infections. Unlike vaccination, which only protects against one serotype, the use of the modified Salmonella as a probiotic could protect against all serotypes by competing for all nutrients that Salmonella can utilize. This product could be used alone, added to any existing probiotic cocktail, or used as a probiotic additive for livestock feed. Animal testing has been performed to ensure safety and efficacy. The novel Salmonella probiotic is aligned with the industry's need to distinguish itself in response to growing demand for documentation of efficacy, substantiation of health claims, and credible clinical trials that support probiotic claims. The product is in the late prototype/ in vivo stage of development and there is continued research being actively pursued.

Commercial Applications

  • Probiotics
  • Agriculture
  • Food safety
  • Animal vaccines
  • Additives to livestock feed

Benefits/ Advantages

  • Known mechanism
  • Potential to protect against all serotypes