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Simple tool for uniform excision and transfer of biological samples

Medical Devices
Research & Design Tools
Equipment
College
College of Medicine (COM)
Researchers
Gadepalli, Venkat Sundar
Licensing Manager
Norris, Francis "Frank"
614-292-5503
norris.641@osu.edu

TS-041193 — A novel tool that offers improved efficiency, convenience, and precision for excision of DNA and protein bands or biological tissues.

The use of gel electrophoresis and other similar techniques is an invaluable part of biological research and has been for several decades. A crucial point in this process is the cutting of specific bands of interest for further sequencing or experimentation. The precision and quality of these cuts…

The Need

The use of gel electrophoresis and other similar techniques is an invaluable part of biological research and has been for several decades. A crucial point in this process is the cutting of specific bands of interest for further sequencing or experimentation. The precision and quality of these cuts is vital to ensure validity and success of further experimentation. Typically, researchers use a blade or scalpel under UV light exposure to cut out bands. This method is inefficient and tedious while also requiring significant expertise. While there are commercially available tools on the market to aid in band or tissue removal, they are either limited in application or not cost-effective.

The Technology

Venkat Sundar Gadepalli at The Ohio State University has created an improved tool for precision cutting of gels that minimizes time spent under UV and improves the quality of excised bands. The design allows users to both cut and lift out the band with one tool, while controlling the width of the desired cut. This approach allows for reduction of cross-contamination, given the improved precision, and also minimized the gel content in the bands, both of which are necessary for successful downstream purification and experimentation. Beyond gel excision, this novel tool can be adapted to a variety of other applications such as tissue banking, biopsy sample handling, and various other procedures involving a "cut and lift" method. Finally, the material composition can be varied between different forms such as disposable plastic and sterilizable metal.

Commercial Applications

  • Gel electrophoresis
  • Biomedical research
  • Nucleic acid and protein research
  • Tissue banks

Benefits/Advantages

  • Enhanced efficiency of gel excision
  • User controlled & uniform sample cutting
  • Quick excision and transfer of tissue specimens