The Need

Metabolomics researchers face a critical challenge in identifying unknown components within complex metabolite mixtures. The absence of efficient and accurate methods hampers their ability to discover new metabolites in biological and biomedical samples. Existing technologies, such as experimental MS and NMR metabolite databases, have limitations in handling diverse metabolites. There is a pressing need for an innovative strategy that can efficiently identify a wide range of metabolites, including amino acids, nucleic acids, polyamines, nucleosides, and carbohydrate conjugates, enabling high-throughput applications in metabolomics research.

The Technology

Introducing SUMMIT MS/NMR, a groundbreaking technology that marries high-resolution mass spectrometry (MS) with Nuclear Magnetic Resonance (NMR) to identify unknown components in complex metabolite mixtures. The approach begins by identifying chemical formulas using accurate masses obtained from MS. It then generates a structural manifold, encompassing all feasible structures consistent with the chemical formulas. NMR spectra of each member of the structural manifold are predicted and compared with experimental NMR spectra to pinpoint molecular structures that align with both MS and NMR data. This pioneering combination of MS and NMR promises unparalleled accuracy and speed in the identification of metabolites.

Commercial Applications

• High-throughput Metabolite Discovery: SUMMIT MS/NMR enables rapid and comprehensive identification of diverse metabolites in complex biological and biomedical mixtures, streamlining the process of discovering new metabolites.
• Biomedical Research: The technology finds applications in the analysis of disease-related metabolites, providing invaluable insights into metabolic pathways and aiding in the development of novel therapeutic targets.
• Pharmaceutical Industry: SUMMIT MS/NMR can facilitate drug metabolite profiling, allowing pharmaceutical companies to better understand the metabolic fate of their compounds and improve drug safety assessment.
• Environmental Monitoring: The technology can be applied in environmental studies to identify and quantify metabolites in complex samples, helping assess the impact of pollutants and contaminants on living organisms.

Benefits/Advantages

• Unparalleled Accuracy: By combining the strengths of high-resolution MS and NMR, SUMMIT MS/NMR delivers exceptionally accurate and reliable results, ensuring confident identification of metabolites.
• Time and Cost Efficiency: The technology's high-throughput capabilities significantly reduce the time and resources required for metabolite identification, accelerating research progress.
• Database-Free Approach: SUMMIT MS/NMR overcomes the need for experimental MS and NMR metabolite databases, expanding the range of metabolites that can be identified and making it an ideal solution for novel metabolite discovery.
• Wide Application Spectrum: From biomedicine to environmental studies and pharmaceutical research, the versatility of this technology empowers researchers across various domains to gain deeper insights into complex metabolite mixtures.
• Advanced Metabolomics Research: With SUMMIT MS/NMR, metabolomics researchers can unlock new frontiers in their studies, pushing the boundaries of what's possible in metabolite identification and analysis.